How to Treat Nephrotic Syndrome in MPGN

MPGN is short for Mesangial Proliferative Glomerulonephritis. It is a kind of glomerular injury caused by immune dysfunction. If the glomeruli are damaged seriously and can not prevent the protein leakage, it will lead to Nephrotic Syndrome.

Immune system is a preventive system in human body and it can defeat the foreign pathological substances by activating the relative antibodies. However, for immune dysfunction, the immune system fails its normal function. As a result, the antigens and antibodies encounter and bind to form large immune complexes that can not dissolve in blood. These immune complexes enter into kidneys through blood circulation and deposit in the mesangial area, which can cause the diffuse proliferation of mesangial cells and extracellular matrix. The proliferation part can insert the space between basilar membrane and epithelial cells resulting in immune injury. Once the basilar membrane and epithelial cells are damaged, they can not realize the barrier function normally. As a result, a mass of protein leak into urine thus resulting in Nephrotic Syndrome.

Therefore, to treat Nephrotic Syndrome in MPGN, it is essential to remove immune complexes, degrade extracellular matrix as well as repair the mesangial cells and epithelial cells.

Here Chinese medicine is recommended to the patients with MPGN complicated with Nephrotic Syndrome. The therapeutic mechanism is as flows:

1. Dilate blood vessels: Chinese medicine can dilate blood vessels so as to relieve the renal ischemia and anoxia. It can provide a favorable environment for repairing the impaired renal cells.

2. Anti-inflammation: It can reduce the infiltration of inflammatory cells to kidneys so as to stop further damage to kidneys.

3. Degradation: Chinese medicine can degrade the extracellular matrix and immune complexes in kidneys. Afterwards, the degraded substances will be excreted out of body in urine. This can inhibit further damage to kidneys.

4. Restoring: The effective ingredients in Chinese medicine can provide some nutrients which can stimulate the self-repairing of the impaired cells.


Once the renal functional cells are restored very well, the kidneys will recover the normal barrier function. In this way, they will be able to prevent the useful substances like protein, red blood cells etc in body. Finally, the protein in urine will disappear and the patients will be able to recover from Nephrotic Syndrome.