What Is Interstitial Nephritis:Causes,Symptoms and Treatment

Interstitial Nephritis also known as Tubulointerstitial Nephritis refers to the inflammation of the space between the renal tubules. The inflammation can impair the kidneys leading renal function decline.

Causes of Interstitial Nephritis

l Interstitial Nephritis includes Chronic Interstitial Nephritis and Acute Interstitial Nephritis. Allergic reaction to a drug is a common cause of Acute Interstitial Nephritis.

l Autoimmune disorders like systemic lupus erythematosus can cause immune complexes deposit in the renal tubules which cause tubule interstitium injury resulting in Interstitial Nephritis.

l Too little potassium and much calcium or uric acid in blood also can cause Interstitial Nephritis.

l Side effects of medications like thiazide diuretics and certain antibiotics such as penicillin, methicillin etc.

Symptoms of Interstitial Nephritis

l In severe case, the patients with Interstitial Nephritis may experience Acute Renal Failure.

l Blood and protein in urine

l Increased or decreased urine output

l Swelling, especially in the part of loose tissues

l Weight gain from retention of fluid

l In some cases of Interstitial Nephritis, some patients may have rash.

Treatment of Interstitial Nephritis

The patients should choose effective treatment depending on the cause of the kidney problems. If Interstitial Nephritis is associated with medications, avoiding using them can relieve the symptoms quickly.

They also can manage their diet and limit the salt and protein intake. It also can delay the disease progression.

If Interstitial Nephritis is caused by autoimmune disorder, the patients should take effective treatment to correct the abnormal immune system, clear up the immune complexes as well as remove the deposited immune complexes in renal tubule. Once the inflammation is eliminated, it is possible to stop the damage to kidneys.


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