Basic Definition of Focal Segmental Glomerulosclerosis (FSGS)

Focal Segmental Glomerulosclerosis( FSGS) is mainly found among people between 20~40 years old and more common in male than female.

As FSGS has latent characteristics, it can not be detected easily. Clinically, about 3/ 4 of the patients have micro-hematuria and nearly 1/ 4 of patients have gross hematuria. Moreover, high blood pressure is a common symptom for patients with FSGS. In addition, some patients develop Nephrotic Syndrome.

FSGS includes primary FSGS and the secondary one. At present, the causes of primary FSGS is unknown. Secondary FSGS may be due to being born with less glomeruli than normal, for example, some people are born with only one kidney. In addition, a series of other factors such as infection, toxins, medicines and some chronic kidney diseases are important factors in causing FSGS. In addition, some researches show that the disease also can be inherited to the offspring, but this case is rare.

FSGS has the following implying meanings: 1. Segmental: it means that some glomeruli are sclerotic, but the left are normal. 2. Focal: for a glomerulus, only a part of the glomerulus has sclerosis. 3. FSGS is also characterized with renal tubular atrophy. Untreated, about 50~70% of patients will develop into Renal Failure.


The following article has introduced the basic information of FSGS. If you want to know more about the disease and its therapies, please consult us on line.

The Newest Treatment for FSGS: Immunotherapy

Focal Segmental Glomerulosclerosis (FSGS) is an autoimmune disease. Immune disorder or deficiency is attributed to the incidence of the disease. Therefore, the right way to treat FSGS is to correct the immune system and repair the impaired kidney structure.

For healthy people, when the external pathological substances as antigens invade into body, the immune system can activate the related antibodies to fight the antigens. After the antigens are eliminated, the immune complexes of antigens and antibodies will be brought out of body through systemic circulation.

However, in some cases, the immune complexes can not be removed and they will enter into kidneys and deposit in the epithelial cells of the glomeruli. These immune complexes attract inflammatory factors gradually thus leading to inflammation of glomeruli. As a result, the epithelial cells are impaired and lost their barrier function. In clinic, the persons are diagnosed with FSGS and will present hematuria, proteinuria etc and other symptoms of FSGS.

The conventional therapies only focus on reliving the symptoms of FSGS and suppressing the inflammation reaction. However, it can not remove the immune complexes. Therefore, the disease often relapses frequently and finally develops into End Stage Renal Failure.

Immunotherapy treats FSGS from its underlying causes. It can remove the immune complexes in kidneys, block the inflammation reaction as well as restore the impaired renal epithelial cells. It can inhibit the renal fibrosis fundamentally and stop the renal function decline from its root cause.


Immunotherapy is aims at correcting the body's own immune system and recover the abnormal protection function of the body. It does not cause side effects to patients at all.