What is the treatment of lupus nephritis

What is the treatment of lupus nephritis

The average survival rate of lupus nephritis within 5-10 years is about 75-85%, and the prognosis is worse in those who have massive proteinuria, hypertension and diffuse proliferative nephritis.

Proper treatment of lupus nephritis can significantly improve his prognosis, increase the life expectancy of patients and improve their quality of life.

General treatment of lupus nephritis

During the active phase of lupus nephritis, patients should avoid strenuous activity or excessive fatigue and have adequate bed rest. Avoid taking medications that can cause or worsen the condition of the disease, such as penicillin, procainamide, etc.

Medicamentous treatment of lupus nephritis

The goal is to maintain small metered-dose hormones or cytotoxic drugs to stabilize the disease, prevent relapse, and reduce side effects.

· Glucocorticoids. This is mainly a drug for the treatment of lupus nephritis, and it can obviously ease the clinical symptoms and improve the prognosis.

Prednisone. Adult patients need to take 0.8-1 mg / kg / day of prednisone for 8-12 weeks, and the dose can be reduced to 0.4 mg / kg when the condition stabilizes and this should last 1-2 years or even longer .

· Methylprednisolone. It is suitable for serious pathological changes and requires intravenous administration. But this can cause infection or retention of water and sodium.

· Cyclophosphamide. It can be used to treat diffuse proliferative lupus nephritis or those that are not sensitive to hormones. However, this can cause many side effects - reverse bone marrow suppression, infection, nausea, vomiting, hair loss, gonadal inhibition, hemorrhagic cystitis, carcinogenic, teratogenic, etc.

· Azathioprine. It is usually combined with a glucocorticoid, and the correct dose is 1-2 mg / kg / day.

· Triptherium glycosides. It is more suitable for use as maintenance therapy for mild symptoms or after lowering the dose of hormones and immunosuppressant. Its main side effects are bone marrow suppression, gonadal inhibition, liver toxicity, menstrual irregularity and gastrointestinal symptoms.

· Cyclosporine. 3-5 mg / kg for 2-32 months, and then reduce by 1 mg / kg every month to 2.5 mg / kg for maintenance therapy. This can cause liver poison, gastrointestinal symptoms, gingival hyperplasia and hairiness.

Leflunomide. It can influence the pyrimidine synthesis of lymphocytes to suppress abnormal immune inflammatory responses. This can cause diarrhea, a rash on the skin, bone marrow suppression, gonadal inhibition, liver toxicity or lung fibrosis, etc.

In addition, herbal medicines and immunotherapy are becoming increasingly widespread in the clinic for the treatment of lupus nephritis, which have been shown to have good consequences. They can also be combined with the above treatments to achieve better therapeutic effects and further reduce the side effects of taking hormones and cytotoxic drugs. If you have problems about the kidney, you can send to us, my mail is Asya.yue@mail.ru, whatsapp / viber +8613292893707.