What Does High Level Creatinine Mean?

Creatinine is usually considered as endogenic creatinine, which is metabolin of muscle. In muscles, creatine is mainly metabolized gradually into creatinine by irreversible non-enzyme dehydration and then creatinine will be released into blood, which is expelled from body with urine. Thus creatinine is closely related with total muscles and it is not easily affected by diet. Creatinine is micro-molecule substance, which is filtered by glomerulus and rarely absorbed by kidney tubules. Creatinine generated in body is almost completely discharged from body with urine, which is usually unrelated with urine volume. Creatinine test is a common measure in clinic used to know renal function.

High level creatinine often means kidney damage. High level of creatinie can comparatively exactly display the damage condition of renal parenchyma but creatinine is not a sensitive index. Generally speaking, because the total muscles in body is comparative stable, creatinine generation is also constant. Whether the levels of Creatinine in blood is high or low, it mainly depends on how much the kidneys expel it. As the kidneys have a great compensation function, so long as one of them maintains a normal function, creatinine will maintain a normal level.Only when GFR declines to one third of normal, will creatinine increase obviously. That is to say human kidney has a great capacity of compensation and when more than half of the renal function has been damaged, creatinine will increase. Therefore creatinine can not reflect renal decline at its early or moderate stage. When the damage of kidney is slight, people usually have no obvious uncomfortable feelings. Consequently, when many people really represent the symptoms such as nausea, vomit and dizzy, in fact their renal damage is serious and the creatinine is obviously increasing.


All patients with high level of creatinine should pay more attention to this condition and take positive treatment timely. In addition, the treatment should repair the damaged kidney effectively, so long as the damaged kidney is well repaired, the renal filtration function will recover and the high level of creatinine will disappear automatically.