How Does IgA Nephropathy Develop?

How does IgA Nephropathy develop? For patients with defect immunity of mucosa, bacterium or virus which can cause infection of upper respiratory tract, gastrointestinal tract or urinary system, enter into body as antigen, combine with abnormal IgA and form immune complex. The immune complex can deposit on the area of glomerular capillary loops and mesangium, which damages glomerular capillary cell and mesangial cell. As a result, mesangial cell can have changes of hyperplasia, proliferation and even lose a function of filtration barrier. At this time, it can not prevent red blood cell from leakage and then red blood cell will be discharged with urine from the body, which represents red blood cell's plus in urine test.

Besides, when mesangial cell is damaged, it can release a series of inflammatory factors, which can aggravate the damage to mesangial cell in turn and make mesangial cell synthesize collagen of type I and type III that are not easily degraded. Consequently, it leads to masses accumulation of extracellular matrixes, promotes glomerulosclerosis and activates the process of renal fibrosis. It can be concluded that IgA Nephropathy is a disease of glomerular capillary mesangial cell caused by immune complex. The symptoms of IgA Nephropathy are a series of discomfortable based on the index of red blood cell of urine test.

Patients with IgA Nephropathy should take positive and proper treatment which should not only treat the symptoms but also treat the disease from the root. Shijiahzuang Kidney Disease Hospital takes Immunotherapy Transplant and Micro-Chinese Medicine Osmotherapy to effectively treat the disease.


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