Proteinuria Is an Important Cause of Renal Failure

Proteinuria is an important factor in causing the progression of Renal Failure. A lot of studies show that proteinuria has nephrotoxicity.

1. The accumulation of blood albumin in the mesangial area can cause injury, proliferation of mesangial cells and the increasing of matrix synthesis thus causing glomerulosclerosis.

2. In normal case, the filtrated protein by glomeruli can be reabsorbed by proximal renal tubule. Moreover, some macromolecular protein can leak into renal tubule if the kidney function is damaged. This part of protein can cause damage to the epithelial cells of proximal renal tubule. Some researches prove that many kinds of protein have toxicity to tubule.

3. Proteinuria can cause renal tubulointerstitial ischemia and anoxia. Proteinuria can aggravate the pathological process thus causing kidney damage. For example: Reabsorbing and digesting mass of protein need extra energy, which can cause renal tubulointerstitial ischemia and anoxia thus causing damage to renal tubular cells. As the oxgen tension is lower than oxgen intension of systemic artery, the renal tubular cells are more sensitive to the oxgen supplement and transport. Therefore, the renal tubular cells can be damaged seriously for ischemia and anoxia.

4. Proteinuria can cause biological change to renal tubular. In many cases, if the patients have proteinuria, their kidneys have hyperplasia of cells thus causing Renal Failure. More and more statistics prove that protein can directly change the renal tubular function thus changing its growth features and phenotype of cell factors and matrix protein.


Therefore, the patients should not neglect the damage of proteinuria and treat it in time so as to decrease its injury to the kidney and avoid Renal Failure.