How to Treat Crescentic Glomerulonephritis Effectively

Crescentic Glomerulonephritis is a kind of serious glomerular disease. It is featured with extensive glomerular crescents (>50%). The small structures (glomeruli) inside the kidneys are damaged seriously. In severe cases of Crescentic Glomerulonephritis, the glomerular filtration rate (GFR) may decline by 50% in 3 month. Therefore, it is very essential for the patients to receive treatment as early as possible once they are diagnosed with Crescentic Glomerulonephritis.

Autoimmunity system plays the major role in pathogenesis of Crescentic Glomerulonephritis. The conventional therapies for Crescentic Glomerulonephritis include corticosteroids for relieving for symptoms and medications that can suppress the immune system. Generally speaking, most of the patients’ illness conditions have obvious improvement after a period of hormonetherapy. However, they also carry the dramatic risk of developing severe complications like slow bone growth for children, hair loss, acne, sugar urine and so on. What’s worse, the medications can not clear up the immune complexes deposited in glomeruli so they are very susceptible to trigger new damage to the renal tissues and cells. Therefore, the hormonetherapy can not achieve the goal of treating Crescentic Glomerulonephritis from its underlying cause.

As the disease is caused by autoimmune dysfunction or autoimmune disorder, Immunotherapy is recommended to the patients with Crescentic Glomerulonephritis.

1. Blocking the immune inflammatory response

When the immune complexes deposit in glomeruli, the body will do its best to remove them out of body leading to inflammatory response. Once the inflammatory occurs excessively, it will damage the renal tissues and cells. Therefore, blocking the abnormal immune inflammatory response is the first step in the treatment of Crescentic Glomerulonephritis.

2. Clearing up the immune complexes in glomeruli

Immune complexes are the underlying cause of renal cells and tissues damage. If they are not removed, they will cause new damage to kidney. Therefore, it’s an essential step to remove the immune complexes out of body in the treatment of Crescentic Glomerulonephritis.

3. Prevent the glomeruli from further damage and repair the damaged renal tissues and cells

The immune inflammatory responses have damaged the renal cells and tissues dramatically. In this case, we need to take measures to prevent the further damage and restore the impaired kidneys. In this way, the renal function improves greatly.


Immunotherapy as a new therapy in the treatment of Kidney Disease, it has showed enormous effect and brought infinite hope to the patients.