How Do You Get Lupus Nephritis

Lupus Nephritis is a serious complication of systemic lupus erythematosus (SLE). Many patients with Lupus Nephritis may complain that they do not have a family history of kidney disease and they are as strong as a bull in daily life, but why they get Lupus Nephritis?

Autoimmune deficiency plays a major role in the pathogenesis of Lupus Nephritis. When the external antigens like colds, infections and so on invade into body, they will activate the antibodies to fight against the antigens. However, as the autoimmunity has deficiency, the antibodies will impair the healthy tissues in body like form immune complex, activate complement, depositing in glomerular basement membrane. Alternatively, autoantibodies may bind to antigens already located in the glomerular basement membrane forming immune complexes in situ. Then the immune complexes promote an inflammatory response by activating complement and attracting inflammatory cells thus leading to inflammation of glomeruli. As a result, a large amount of protein will leak into urine leading to proteinuria, edema, and hypertension and so on.

The conventional therapies for Lupus Nephritis mainly include hypertension medicines, hormones and so on. After a period of treatment, most of the patients can get a marked improvement. However, even mild infections can trigger the disease again. That is because the medicines and hormone can only treat the symptoms of Lupus Nephritis, but can not treat the causes.


As autoimmunity deficiency plays the main role in causing Lupus Nephritis, the patients need to improve their autoimmunity and restrain the abnormal immune reaction. Moreover, the immune complexes are the harmful substances leading to inflammatory response to glomeruli. Therefore, the patients should choose therapies that can clear away the immune complexes out of body and then repair the impaired glomerular basement membrane. In this way, the patients will be able to improve their renal function enormously. What's worse, once the autoimmunity improves, it will decrease the relapsing of Lupus Nephritis. If you want to get more information about the prevention, diet of Lupus Nephritis and other aspects, you can consult our experts on line or email to kidney-treatment@hotmail.com.