How Is the Prognosis of Lupus Nephritis

Commonly, the prognosis of Lupus Nephritis is not good. However, if the patients can receive treatment as early as possible, they can delay the disease progression and avoid Renal Failure.

Lupus Nephritis is a serious complication of systemic lupus erythematosus. Since 1990s, the survival rate of patients with Lupus Nephritis is 83~92% in 5 years and 74~84% in 10 years. After diagnosis of Lupus Nephritis, the patients may develop into End Stage Renal Failure in 5~10 years. In recent years, with the development of medical technology, the research on the prognosis of Lupus Nephritis, the survival rate can reach 97% in 10 years and 82% in 20 years. End Stage Renal Failure is the most important cause of increased mortality for the patients with systemic lupus erythematosus. The mortality for the patients with Lupus Nephritis is 2 times as high as those only have lupus. Therefore, it is very important for the patients to know the factors that influence the prognosis of Lupus Nephritis.

Age: At present, there is not a common view on if age can influence the prognosis of Lupus Nephritis. According some researches, if the onset age is above 50 years old, the prognosis of Lupus Nephritis is bad. However, some researches prove that although the onset age is above 50 years old and the patients have obvious decline in creatinine clearance rate and high blood pressure, but the population develop End Stage Renal Failure has no difference from the young patients.
Usually, the prognosis of Lupus Nephritis is worse in man than woman.

The clinical symptoms and lab exams prove that if the patients with lupus have serological abnormality like the serum complement declining, circulatory immune complex increasing and so on, they are more likely to develop into Lupus Nephritis. Anemia is an important index in reflecting bad prognosis of Lupus Nephritis. If the patients have renal insufficiency, high creatinine level or decline in glomerular filtration rate, serious proteinuria or Nephrotic Syndrome, the prognosis of Lupus Nephritis is bad.


In recent years, with the regenerative medicines development, the application of Immunotherapy has improved the prognosis of Lupus Nephritis greatly. The Immunotherapy can repair the damaged renal intrinsic cells so as to restore the kidney structure. A good prognosis of Lupus Nephritis certainly and mainly depends on an effective treatment. If you want to get more information on Lupus Nephritis treatment, prevention, diet and so on, please email to kidney-treatment@hotmail.com.