What Is the Treatment for MPGN

Membranoproliferative glomerulonephritis (MPGN) is an autoimmune disorder which affects the filters in kidneys. Although the prognosis of MPGN is good, it is quite pone to progress into Renal Failure if the patients can not get proper treatment in time. After many years' research, a new therapy—immunotherapy is applied successfully in treating kidney disease.

How does MPGN occur?

Our human body has a powerful immune system which can prevent the harmful substance invading into body by producing antibodies. However, in some cases, the immune system can not function well. As a result, the antibodies fail to defeat the harmful substances known as antigens. As a result, the antibodies and antigens form immune complexes to lodge in the kidney, which can cause inflammation and damage to the kidney itself.

How to treat MPGN?

Immunotherapy is a kind of biotherapy. It plays the following roles in treating MPGN.

1. It can inhibit the inflammation immediately by using a series of immunosuppressive agents with low side effects. In this way, it can stop further damage to kidneys effectively.

2. Immune complexes are outside pathological substances. Therefore, it is not possible for them to exist in kidneys for too long. Immunotherapy can clear up the immune complexes in blood and degrade the immune deposits in kidneys completely.

3. The underlying cause of MPGN is autoimmune dysfunction. Immunotherapy can stimulate the body to produce normal immune cells to rebuild the immune system. Hence, it can prevent the relapse of MPGN completely.

What is achievable using immunotherapy?

Eliminate symptoms like proteinuria, hematuria, swelling, high creatinine level etc.

Improve renal function by repairing glomeruli.

Rebuild immune system.


After the above systemic treatment, the patients with MPGN will have overall health improvement and avoid developing Renal Failure.