Type 2 (ⅱ) MPGN New Treatment

Membranoproliferative glomerulonephritis (MPGN) is a kidney disease, in which the filters (glomeruli) in kidneys are impaired. According to the pathological changes, MPGN can be divided into three types: type 1, type 2 and type 3 MPGN.

Type 2 MPGN is also called dense deposit disease. Under microscope, continuous and dense immune deposits are found along the basement membrane of the glomeruli and tubules. The immune deposits can attract inflammatory factors ceaselessly and cause inflammation response in kidneys. If the inflammation is not inhibited, it will impair the glomeruli drastically and causes complete Renal Failure finally. So, how to treat type 2 MPGN effectively?

As mentioned above, type 2 MPGN is mainly caused by autoimmune disease. Our human body has a powerful immune system which can defeat the outside harmful materials such as germs to keep body healthy.

However, in autoimmune disorder, the immune system can not tell the difference between the outside harmful stuffs and those inside body like organs and tissues.

In type 2 MPGN, the immune system attacks kidneys mistakenly. When outside harmful substances (antigens) invade into body, the immune system produce relevant antibodies. However, for autoimmune dysfunction, the antibodies fail to defeat antigens. As a result, the antigens and antibodies form immune complexes and then deposit in basement membrane of the glomeruli and tubules thus inducing type 2 MPGN.

Therefore, to treat type 2 MPGN effectively, the treatment should focus on removing the immune deposits and restoring the impaired glomeruli. The new treatment—immunotherapy has showed enormous therapeutic effect in treating MPGN.
Immunotherapy is a brand new biotherapy. It aims at recovering the body’s self-healing ability.

In treating type 2 MPGN, immunotherapy can clear up the immune complexes in kidneys and blood. Therefore, it can inhibit going on of the inflammation reaction.

Immunotherapy can control the symptoms of type 1 MPGN by restoring the impaired glomeruli. It can improve renal function from its underlying cause.


Immunotherapy can help rebuild the patients’ immune system by application of Immunotherapy. Hence, it can prevent the relapse of type 2 MPGN completely.