What Does Abnormal Level of Creatinine Mean

Creatinine is usually considered as endogenic creatinine, which is metabolin of muscle. In muscles, creatine is mainly metabolized gradually into creatinine by irreversible non-enzyme dehydration and then creatinine will be released into blood, which is expelled from body with urine. Thus creatinine is closely related with total muscles and it is not easily affected by diet. Creatinine is micro-molecule substance, which is filtered by glomerulus and rarely absorbed by kidney tubules. Creatinine generated in body is almost completely discharged from body with urine, which is usually unrelated with urine volume. Creatinine test is a common measure in clinic used to know renal function.

High level of creatinine

Creatinine above normal level often means kidney damage. It can comparatively exactly display the damage condition of renal parenchyma but creatinine is not a sensitive index. Only when GFR declines to one third of normal, will creatinine increase obviously. That is to say human kidney has a great capacity of metabolism. When the damage of kidney is slight, people usually have no obvious uncomfortable feelings. Consequently, when many people really represent the symptoms such as nausea, vomit and dizzy, in fact their renal damage is serious and the creatinine is obviously increasing.

Low level of creatinine


All patients with low or high creatinine should highly pay attention to this condition. Creatinine in human body mainly produced by muscles metabolism with creatine, which is expelled from body through kidney. Generally speaking, because the total muscles in body is comparative stable, creatinine generation is also constant. Whether the levels of Creatinine in blood is high or low, it mainly depends on how much the kidneys discharge it. As the kidneys have a great compensation function, so long as either of them maintain function, creatinine will maintain a normal level. That is to say when more than half of the renal function has been damaged, creatinine will increase. Therefore creatinine can not reflect renal decline at its early or moderate stage.