What Are Symptoms of Mesangial Proliferative Glomerulonephritis

Mesangial Proliferative Glomerulonephritis is a kind of glomerular disease charactered with diffuse mesangial cell's proliferation and different severity of mesangial matrix's hyperplasia. It is a rare primary glomerulonephritis, which can not be easily observed in its early stage. It is every important to know the symptoms of Mesangial Proliferative Glomerulonephritis and take treatment timely.

Mesangial Proliferative Glomerulonephritis can be found in any ages with an higher incidence among children and young people of 16 to 30 years old. In addition, male risks a higher incidence than female. Symptoms at early stage are often not so obvious. In addition, Mesangial Proliferative Glomerulonephritis often attacks after infection of the upper respiratory tract, the incidence of which is among 30.8%～40.3%.

Clinical manifestations of Mesangial Proliferative Glomerulonephritis are various, which includes manifestations of various primary glomerulonephritis. Slight symptoms display hematuria, proteinuria or chronic glomerulonephritis, but the severe symptom of it is Nephrotic Syndrome.

Among patients, more than 30 percent of them represents microscopic hematuria, about 20 to 30 percent of patients have symptom of gross hematuria. Besides, proteinuria can be found with different severity from slight proteinuria to serious proteinuria. Besides, about 30 percent patients have symptom of slight hypertension. At the primary stage, patients usually have normal renal function and 10 to 25 percent patients can suffer declined renal function at late stage.
Further more, the symptoms are related with pathological changes, for example obvious diffuse mesangial proliferation will tend to persistent proteinuria or progressive Renal Insufficiency. Patients with pathological changes of mesangial proliferation and focal segmental sclerosis will easy develop into Renal Insufficiency. For those patients with unconspicuous mesagial proliferation, they have a better prognosis.


Attention: as symptoms of Mesangial Proliferative Glomerulonephritis are not obvious, people should take physical examination on regular intervals in order to avoid delaying condition for treatment.