Side Effects of Hormone in Treating Primary Nephrotic Syndrome

Primary Nephrotic Syndrome is caused by Primary Glomerular Diseases. As Primary Glomerular Diseases are immune-mediated diseases. Therefore, hormone has an obvious effect in treating Primary Nephritic Syndrome. However, at the same time, hormone also has many side effects in the treatments of Primary Nephritic Syndrome.

1. Infection

Hormone has an enormous effect in restricting immunity. Therefore, it the patients with Primary Nephrotic Syndrome use hormone over time, it can cause their immunity to decline thus cause them are more likely to have infection. When patients have infection, usually their inflammation is not obvious so the patients can not notice the inflammation.

2. Hypertension and edema

Usually the patients with Primary Nephrotic Syndrome have Hypertension and edema when using hormone, which is caused by retention of water and sodium caused by hormone. Therefore, the patients should observe those symptoms carefully so as to receive antihypertensive therapy and diuresis therapy in time.

3. Gastric ulcer

Hormone can improve the secretion of gastric acid and pepsase thus inducing gastric ulcer and even bleeding and perforation. Therefore, if the patients with Primary Nephrotic Syndrome, they should be cautious when taking hormone.

4. Osteoporosis

Hormone can restrain the activity of bone cells, absorption of calcium thus hindering the bone formation, which can further lead to osteoporosis. Therefore, if the patients, especially the elder, they should take some vitamin D and calcium tablet in time.

5. Electrolyte disturbance

Hormone can increase the excretion of potassium thus causing hypokalemia.

6. Steroid glycosuria

Hormone can decrease the utilization rate of insulin and enhance neoglycogenesis, which can make blood sugar increase thus causing glycosuria.

7. Mental disorder

If the patients with Primary Nephrotic Syndrome use hormone, it can cause them mental disorders such as insomnia.

8. Changes in body shape

Long term using hormone can cause changes in body shape such as skin cracks, moon-shaped face, obesity, amyotrophy in limbs and so on.


As hormone can cause so many side effects on patients with Primary Nephrotc Syndrome, they should be cautious when using hormone with their doctors’ guidance. What the patients should firstly do is to choose an effective therapy instead of using hormone.