Is Diabetes Kidney Disease Reversible

Diabetes Kidney Disease is commonly seen among people with a long history of disease. It is the most common cause of Renal Failure in the western countries. So, is Diabetes Kidney Disease reversible in its early stage?

Firstly, how does Diabetes cause kidney injury?

1. Genetic factors

* Diabetes Kidney Disease usually clusters in a family. If there is a family history, its morbidity can increase to 33~83%. In other cases, the morbidity is only 10~17%.

* It may be related to the polymorphism of ACE gene.

2. Metabolic disorder

* High blood glucose can thicken the glomerular basilar membrane and increase the excretion of proteins thus causing glomerular filtration rate (GFR) to decline.

* High-cholesterol can speed up falling speed of GFR and glomerular sclerosis progression.

* High blood pressure can promote occurrence and development of glomerular sclerosis. If there is a family history of primary high blood pressure, the morbidity of Diabetes Kidney Disease is 3 times as high as those without family history of high blood pressure.

* Hemodynamic changes

In the early stage of Diabetes Kidney Disease, the hemodynamic changes can cause enlargement of kidneys. The increased renal blood volume can elevate the pressure in glomeruli thus causing extra burden to kidneys.

Is Diabetes Kidney Disease reversible in its early stage?

If Diabetes Kidney Disease keeps in its stage 1 or 2, it is possible to reverse it because the kidneys are not damaged yet, but only have enlargement. In most cases, as the patients do not have any discomforts or symptoms, they usually miss the early treatment.

Generally speaking, when they have proteinuria or high blood pressure, it has at least developed into stage 3. If so, it is very difficult to reverse the disease by the conventional therapy. What they only can do is to control high blood pressure and reduce protein leakages etc. Therefore, early inspection is very important for the prevention of kidney damage in Diabetes. For the patients with Diabetes, they are recommended to take urine microalbumin test once in every half year. It can imply the early kidney damage clearly.


If you have experienced serious kidney damage and want to know how to restore the damaged kidneys, Immunotherapy may be your best option.