Why Do Patients with Nephrotic Syndrome Have Protein in Urine

Proteinuria is a main clinical manifestation of Nephrotic Syndrome. In one day, the patients can loss 3.5 proteins in urine and even more, which is the primary cause of other symptoms and renal damage. Therefore, it is very important for the patients with Nephrotic Syndrome why they have protein in urine and then receive relative treatments in time.

For the patients with Nephrotic Syndrome, various pathological changes damage the glomerular filtration barrier so its permeability to protein increases. As a result, the protein will leak into urine through glomerular filtration membrane.
The glomerular filtration barrier includes two types: 1. Mechanical barrier: In normal condition, the hole of filtration membrane can limit 18~42 nm molecules to pass and totally prevent the protein molecules that larger than 42 nm from passing. 2. Electronic barrier: Under normal condition, the filtration barrier carries negative charge. These negative charges can prevent the protein with negative charge from passing through filtration membrane. For the patients with Nephrotic Syndrome, the pathological changes can damage the above two barriers and make enlarge the filtration hole or make the negative charge disappear. If the filtered protein exceeds the reabsorption ability, the protein will be excreted into urine.

From the cause of protein in the patients with Nephrotic Syndrome, the patients should repair the damaged filtration if they want to treat proteinuria. As the glomerular filtration membrane is composed of renal intrinsic cells, it is the first step to repair the injured renal intrinsic cells. On this point, Immunotherapy has showed its tremendous effect.


Under right condition, Immunotherapy can differentiate into new cells with specific functions to replace the dead cells. In repairing glomerular filtration membrane, the Immunotherapy can different into new cells to replace the necrotic intrinsic cells to play their roles. Moreover, Immunotherapy can secrete some nutrients that can promote the repairing of the damaged renal intrinsic cells. As a result, the glomerular filtration function can improve greatly. Once the glomerular filtration membrane is repaired, the protein in urine will disappear. If you want to know more about symptoms, diagnosis or nursing care and other aspects of Nephrotic Syndrome, please email to kidney-treatment@hotmail.com or consult us on line.