Pathogenesis and Treatment of Hyperuricemic Nephropathy

Hyperuricemic Nephropathy is a kind of kidney damage caused by hyperuricemia. Hyperuricemic Nephroapthy is the diagnosis result in the traditional medicines. Based on the modern cytology, it refers to the pathological changes in renal tubular epithelial cells.

The pathogeny of Hyperuricemic Nephropathy is the metabolic disorder of purine. More uric acid is produced or less is excreted thus causing hyperuricemia. If the patients can not control hyperucemia over time, it will cause uric acid to deposit in renal mesenchyme tissues and medulla. In the acute period, there are inflammatory cell infiltrations around urate. Then the glomerular basilar membrane thickens, glomeruli have fibrosis, renal tubular atrophy degeneration, mesenchyme blood vessels widen. From pathology, it is chronic interstitial nephritis and is also called renal tubular epithelial disease. The urate crystal causes inflammatory reaction thus damaging the renal tubular epithelial cells and causing the mesenchymal fibroblasts and renal tubular epithelial cells to have phenotypic transformation and release inflammatory medium. As a result, renal tubular epithelial cells and mesenchymal fibroblasts to transfer into myofibroblastsm, which then lead to renal interstitial fibrosis. In the period of inflammatory reaction period, the patients nearly do not have any symptom.
However, once it develops into the period of fibrosis formation, the urinary routine examination shows hematuria, proteinuria, and declined specific gravity and so on. Also the patients themselves also can feel increased excessive urination at night.


From the pathology of Hyperuricemic Nephropathy, repairing the damaged renal tubular epithelial cells and block renal fibrosis is the key in treating the disease. On this point, traditional Chinese medicines play an important role. Meanwhile, the western therapies have its unique effect in treating the inflammatory reaction. Therefore, the combined application of traditional Chinese medicines and western therapies can give a good therapeutic effect for the patients with therapies just treat the inflammatory reaction caused by the disease, but not treat the disease from its fundamental causes Hyperuricemic Nephropathy.