Pathogenesis of Hepatitis B Virus Associated Glomerulonephritis

Hepatitis B Virus Associated Glomerulaonephritis is the diagnosis result in the conventional medicines based on histology. However, in the present medical diagnosis, Hepatitis B Virus Associated Glomeruonephritis refers to the pathological changes in the epithelial cells of glomerular blood capillaries. How do you get Hepatitis B Virus Associated Glomerulonephritis?

After hepatitis B virus invading into body, as external antigen, they will combine with the antibody to form massive immune complex C3, IgG, IgM and so on to deposit in glomerular blood capillaries loops and mesangial area. Consequently, it can damage the glomerular blood capillaries epithelial cells. As a result, the barrier function of glomerular epithelial cells is damaged. The protein will leak into urine and then be discharged out of body.

In addition, Hepatitis B Virus Associated Glomerulaonephritis is also related to autoimmune damage. In the patients with chronic HBV infection, various kinds of autoimmune antibodies can be checked out such as DNA antibody, smooth muscle antibody, and anti-liver cell membrane antibody and so on. At the same time, for patients with Hepatitis B Virus Associated Glomerulaonephritis, their serum C3 level usually declines, circulatory immune complex increases. These immune abnormalities are basic pathogenesis of the disease.

Moreover, HBV can affect kidney tissues directly. Besides liver cells, HBV can infect other cells such as pancreatic acinar cells, monocyte and so on.


Knowing the pathogenesis can help patients have a better understanding of Hepatitis B Virus Associated Glomerulaonephritis. In order to get an effective therapeutic effect, the patients should receive proper treatment based on the fundamental causes of the disease.