Complications of Renal Failure for PKD patients

At present, there is no cure for Polycystic Kidney Disease (PKD). If the patients can not receive effective treatment in time, more than half of them will develop Renal Failure. With their renal function declining, the patients will have a series of complications. As follows:

1. After the renal function of PKD patients begin to fail, they will have abnormal digestive symptoms such as nausea, vomit, poor appetite, urine smell in mouth and so on. What’s worse, some patients even have digestive tract mucous membrane erosion, ulcer thus causing bleed in digestive tract. As a result, the patients will have bleed in their stool. Some patients may have massive haemorrhage in their digestive tract, which even can cause death.

2. The PKD patients with Renal Failure usually have Hypertension. At End Stage Renal Failure, the incidence of Hypertension can reach above 90%. Therefore, the patients are very likely to have eyeground pathological changes and cardiovascular diseases.

3. Anemia is also a common complication of PKD patients with Renal Failure. After their disease develops into End Stage Renal Failure, nearly 100% of patients will have anemia. It is caused by the following factors:

(1) The patients often have vomit, nausea, poor appetite so the patients can not get sufficient raw material of blood.

(2) Uremic toxins cause damage to marrow thus declining the blood cell production.

(3) The fragility of red cells increases thus shortening the life expectancy of red cells.

(4) The patients often have bleed in different body part thus causing red cells lose.

(5) Kidney can not secrete enough hemopoietin.

4. Usually, the patients with Renal Failure often have endocrine disorder.

Kidney is not only an excretory organ, but also an important endocrine organ. Many endocrine hormones such as insulin is degraded and excreted in kidney. At the same time, many endocrine hormones such as hemopoietin are secreted in kidney. Therefore, the patients with Renal Failure often have endocrine disorder.
In addition, the accumulation of uremic toxins and metabolin also can stimulate or restrain the production of some endocrine hormone. Fox example, uremic toxins restrain the growth hormone and sex hormone production.

Besides the above complications, the PKD patients with Renal Failure also have neuropathy, respiratory diseases, metabolic disorder, bone disease, skin disease and so on. Therefore, all patients with PKD should receive treatment as early as possible so as to prevent its complications.


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