Latest Treatment of Mesangial Proliferative Glomerulonephritis

Mesangial Proliferative Glomerulonephritis is featured by mesangial cells proliferation and mesangial matrix increasing. Generally speaking, the prognosis of the disease is good. However, if the mesangial cells proliferation severe along with focal segmental glomerulosclerosis (FSGS) renal interstitial fibrosis, its prognosis is extremely poor. For this part of patients, the relapse rate after kidney transplant is as high as 40%~60%. Therefore, it is very important for the patients with Mesangial Proliferative Glomerulonephritis to take treatment as early as possible.

Autoimmunity plays the major role in Mesangial Proliferative Glomerulonephritis. In most cases of the disease, the patients had a medical history of infection. When external pathological substances (antigens) invade into body, the relative antibodies are activated to deal with the pathological substances. In normal condition, the antibodies can defeat the antigens. Finally, the body recovers normal from illness. However, some persons have immune deficiency so their immune system is activated improperly. The activated antibodies and antigens combine to form circulatory immune complexes and then deposit in mesangial are thus leading to mesangial cells proliferation. These immune complexes attract inflammatory factors thus impairing the kidneys. In clinic, the persons are diagnosed with Mesangial Proliferative Glomerulonephritis.

After the above analysis of the underlying causes of Mesangial Proliferative Glomerulonephritis, it can be seen that correcting abnormal immune system and removing the immune complexes is the key in treating the disease and stopping its further damage to kidneys. Immunotherapy has showed its effective efficiency in realizing the above therapeutic goals.

Immunotherapy can clear up the abnormal antigens and antibodies so as to stop the formation of immune complexes. Also it can promote the excretion of the immune complexes by degrading the complexes and improving the clearance ability of the body.


Also, immunotherapy can provide some micronutrients for repairing the impaired renal tissues and cells. In this way, the renal function will be improved enormously. In this way, the patients will be able to avoid dialysis or kidney transplant.