Amyloidosis Can Cause Kidney Damage

Amyloidosis is a kind of chronic metabolic disease due to the amyloid protein deposition in tissues and cells. It can cause damage to multiple organs and tissues. In all cases of amyloidosis, approximately 95% of the persons have kidney damage in varying degrees.

However, in the early stag of kidney damage, the patients do not present obvious symptoms so the patients often miss the optimal therapeutic opportunity. In kidney damage caused by amyloidosis, immune disorder plays the major role.

In healthy condition, when pathogen invades body, the immunity system will start work to kill them. After the pathogens are eliminated, the immune response will stop afterwards. However, if the immune function is disordered, it will not be able to function normally. When the pathogens are removed, the immune response still goes on, which can cause excess protein to form in blood. When these proteins deposit in kidneys, the body will arouse an inflammatory response to remove the proteins. The inflammatory response will impair renal tissues and cells thus causing kidney damage.

Therefore, inhibiting the abnormal activation of immune system and clearing up the deposited protein is the key for the prevent kidney damage. Here immunotherapy is suggested to the patients with kidney damage due to amyloidosis.
On one hand, the blood purification in immunotherapy can clear up the abnormal proteins in blood so as to decline protein deposition.

On the other hand, immunotherapy can suppress the abnormal immune activation and regulate immune function.


After the systemic immunotherapy treatment, it can prevent the renal function decline effectively and avoid the chance of developing Renal Failure.