How does Polycystic Kidney Disease Develop into Renal Fibrosis

Any kind of kidney disease will follow the process of renal fibrosis, which is very difficult to treat once they progress into Urmeia( End-Stage Renal Failure). During this period, the kidney functions have been greatly damaged. However, if patients with Polycystic Kidney Disease do not receive positive measures to control it, it can also develop into Uremia without exception. How does Polycystic Kidney Disease develop into renal fibrosis and when is the best time to prevent the occurrence to renal fibrosis.

Before half of the nephrons are damaged, people do not present abnormal symptoms, while, renal fibrosis has already developed into the middle stage. If 80% of the kidneys are damaged, patients then enter into the Renal Failure stage and a lot of symptoms like acidosis will appear. The kidneys will be in a state of ischemia and anemia, which triggers the onset of renal fibrosis. A series of renal toxicity factors and growth factors( PDGF,TGF-β) will be produced at this period, which will stimulate the epithelial cells phenotype’s transformation, producing mybrofibroblasts and secrecting extracellular matrix (ECM).

Therefore, it is important to prevent the process of renal fibrosis, which means to reverse the damaged kidney intrinsic cells and recover the kidney functions. As for the prevention of renal fibrosis caused by Polycystic Kidney Disease, it has the following aspects.

1. Shrink the cysts to reduce the pressure on the kidneys.

2. Repair the damaged kidney tissues.

It is better to treat Polycystic Kidney Disease as early as possible especially when the kidney function has not been damaged yet. The life expectancy can prolong even with cysts in their kidneys.


Here we recommend Micro-Chinese Medicine Osmotherapy and Immunotherapyation in Shijiazhuang Kidney Disease Hospital. Many patients have got a satisfactory result through the two therapies. The kidney cysts can shrink effectively and decrease the damage of kidney functions to the largest extent. If you have other questions of your illness condition or our therapies, please send email to kidney-treatment@hotmail.com.