High Creatinine in Polycystic Kidney Disease Group

Actually, in the early stage of Polycystic Kidney Disease, the creatinine level is normal and the kidney function is also normal. Once this disease aggravate, creatinine will increase due to kidney damage caused by cysts enlargement. Once creatinine level increase, it means that the disease has progressed into renal insufficiency or renal failure stage.

Cysts of PKD patients keep growing continuously and these cysts can compress surrounding kidney tissue, causing damage to healthy nephron. In the end stage Polycystic Kidney Disease, patients' kidneys are much larger than normal size, and no healthy nephron can be seen through microscope.

When kidneys are damaged by these cysts, injured renal inherent cells will have phenotype change, forming pathological change, which can not only stimulate renal mechanocyte to turn into myofibroblast, but also cause healthy renal tissue to have the same pathological change. For this reason, such pathological change spread from spot to area, then the whole kidney. This means this disease develops into renal dysfunction stage. At this moment, due to continuous kidney damage, kidney function of excreting waste declines, and then toxins like creatinine, urea, etc, will accumulation in body. Therefore, serum creatinine increases and urine creatinine decreases on one hand and on the other filtrating rate of bilateral kidneys reduce. Meanwhile, patients may also have symptoms of High Blood Pressure, serious Edema and so on.


From the above, it can be found that if Polycystic Kidney Disease patients want to reduce their creatinine level, they should start with reducing kidney damage, which is on the basis of controlling cysts enlargement. Once cysts can be controlled and kidney damage can be repaired, kidney function will get an improvement and then creatinine level decreases gradually. If you need more information about this, you can email to kidney-treatment@hotmail.com or consult us online.