Nephrotic Syndrome:Causes,Symptoms,Complications,Treatment

Nephrotic Syndrome is not a single disease, but a set of symptoms related to kidney dysfunction including massive loss of protein in urine, low blood protein levels, high blood cholesterols and swelling.

Causes of Nephrotic Syndrome

Nephrotic Syndrome is caused by immune abnormality or disorder. Our human body has a powerful immune system to prevent the foreign microorganisms such as bacteria and viruses from invading into body. However, in some cases, the immune system is activated improperly in response to antigens that may not have potential to cause disease. When antibodies encounter and bind to antigens in blood, they form very immune complexes. Afterwards, these immune complexes will flow into kidneys and deposit in the glomeruli. The body will start an inflammatory response to try to remove them. Finally, the inflammation can impair the function of glomeruli. As a result, the permeability of the glomerular filtration membrane improves and a lot of protein will be filtered out into urine. In clinic, the persons are diagnosed with Nephrotic Syndrome.

Symptoms of Nephrotic Syndrome

* Swelling: It is a major symptom in Nephroitc Syndrome and especially occurs around the eyes, faces and ankles. In severe case, the persons with Nephrotic Syndrome may experience swelling in belly area.

* Foamy urine: It is caused by the protein loss in urine.

* Weight gain: It is due to the retention of fluid in body.

* High blood pressure: It affects both young and old persons with Nephrotic Syndrome.

Complications of Nephrotic Syndrome

* Infection: The persons with Nephrotic Syndrome have a high risk of developing infection.

* Chronic Renal Failure: Nephrotic Syndrome may cause the kidney function decline gradually over time.

* Acute Renal Failure: If the glomeruli are impaired seriously, a mass of wastes products will build up quickly in blood resulting renal function to decline at a fast speed.

* Malnutrition: Proteins are the main sources supplying energy for the body. As a mass of protein loss in urine can result in malnutrition.

* Blood clots: The proteins in blood can help prevent clotting. Therefore, the loss of blood proteins can increase the chance of developing blood clots in the veins.

Treatment of Nephrotic Syndrome

Nephrotic Syndrome is a complex immunological disease affecting glomeruli. The conventional therapies mainly focus on the symptoms of the disease. The experience shows that the conventional along is not enough to treat Nephrotic Syndrome effectively. Clinical practices prove that immunotherapy can help the disease more effectively.

Immunotherapy is a great achievement medical field and brings new hope to the persons with intractable disease. As for the treatment of Nephrotic Syndrome, it aims at eliminating symptoms from its underlying causes. Immunotherapy can suppress the abnormal immune response, block the formation of immune complexes as wells as clear up the immune complexes deposited in blood and glomeruli. In this way, it can inhibit further damage to kidneys effectively.

Moreover, immunotherapy can restore the impaired renal tissues and correct the immune disorder as well as help rebuild immunity system. Therefore, it can make the persons with Nephrotic Syndrome avoid the relapse of the disease.


Immunotherapy is a breakthrough in the field of Kidney Disease treatment and makes it possible for the persons to avoid dialysis or kidney transplant.

Latest Treatment of Mesangial Proliferative Glomerulonephritis

Mesangial Proliferative Glomerulonephritis is featured by mesangial cells proliferation and mesangial matrix increasing. Generally speaking, the prognosis of the disease is good. However, if the mesangial cells proliferation severe along with focal segmental glomerulosclerosis (FSGS) renal interstitial fibrosis, its prognosis is extremely poor. For this part of patients, the relapse rate after kidney transplant is as high as 40%~60%. Therefore, it is very important for the patients with Mesangial Proliferative Glomerulonephritis to take treatment as early as possible.

Autoimmunity plays the major role in Mesangial Proliferative Glomerulonephritis. In most cases of the disease, the patients had a medical history of infection. When external pathological substances (antigens) invade into body, the relative antibodies are activated to deal with the pathological substances. In normal condition, the antibodies can defeat the antigens. Finally, the body recovers normal from illness. However, some persons have immune deficiency so their immune system is activated improperly. The activated antibodies and antigens combine to form circulatory immune complexes and then deposit in mesangial are thus leading to mesangial cells proliferation. These immune complexes attract inflammatory factors thus impairing the kidneys. In clinic, the persons are diagnosed with Mesangial Proliferative Glomerulonephritis.

After the above analysis of the underlying causes of Mesangial Proliferative Glomerulonephritis, it can be seen that correcting abnormal immune system and removing the immune complexes is the key in treating the disease and stopping its further damage to kidneys. Immunotherapy has showed its effective efficiency in realizing the above therapeutic goals.

Immunotherapy can clear up the abnormal antigens and antibodies so as to stop the formation of immune complexes. Also it can promote the excretion of the immune complexes by degrading the complexes and improving the clearance ability of the body.


Also, immunotherapy can provide some micronutrients for repairing the impaired renal tissues and cells. In this way, the renal function will be improved enormously. In this way, the patients will be able to avoid dialysis or kidney transplant.

IgA Nephropathy: Symptoms and Prognosis

IgA Nephropathy is a kidney disorder caused by immune complexes deposition in glomeruli. It mainly affects people between 16~35 years old.

Symptoms of IgA Nephropathy

* Gross hematuria: It usually occurs a short time (24~72 hours) later after upper respiratory infection. Sometimes, the persons are also accompanied by mild systemic symptoms like muscle pain, painful urination, low fever ad back pain. The gross hematuria usually occurs frequently and it may convert to microscopic hematuria after a period.

* Microscopic hematuria with or without asymptomatic proteinuria: It is very common among children and adults.

* Proteinuria: It is usually mild and the urine protein is less than 1 gram in 24 hours. However, in a minority of cases, the persons may suffer from massive proteinuria and even Nephrotic Syndrome.

* Rapidly progressive nephritis syndrome: It is rare. The persons usually have persistent gross hematuria, massive of proteinuria. The renal function aggravates in a very short time along with edema and mild or moderate high blood pressure.
* Others: For the patients with typical clinical symptoms, they often experience intense pain in back and abdomen along with kidney stone. In this case, the disease is usually are misdiagnosed as kidney stone, pyelonephritis or acute gastroenteritis.

Prognosis of IgA Nephropathy

The following factors can influence the prognosis of IgA Nephropathy.

* The prognosis of IgA Nephropathy is poorer in male than female. What’s more, the earlier the disease starts, the worse its prognosis will be.

* For the persons with frequent gross hematuria, the prognosis is bad.

* If the persons with IgA Nephropathy develop massive proteinuria or Nephrotic Syndrome, the prognosis is not good.

* If the persons with IgA Nephropathy have a poor control of blood pressure, the prognosis is bad.


* If the pathological change in IgA Nephropathy such as crescent formation, interstitial fibrosis etc, the prognosis is bad.

The Newest Treatment for FSGS: Immunotherapy

Focal Segmental Glomerulosclerosis (FSGS) is an autoimmune disease. Immune disorder or deficiency is attributed to the incidence of the disease. Therefore, the right way to treat FSGS is to correct the immune system and repair the impaired kidney structure.

For healthy people, when the external pathological substances as antigens invade into body, the immune system can activate the related antibodies to fight the antigens. After the antigens are eliminated, the immune complexes of antigens and antibodies will be brought out of body through systemic circulation.

However, in some cases, the immune complexes can not be removed and they will enter into kidneys and deposit in the epithelial cells of the glomeruli. These immune complexes attract inflammatory factors gradually thus leading to inflammation of glomeruli. As a result, the epithelial cells are impaired and lost their barrier function. In clinic, the persons are diagnosed with FSGS and will present hematuria, proteinuria etc and other symptoms of FSGS.

The conventional therapies only focus on reliving the symptoms of FSGS and suppressing the inflammation reaction. However, it can not remove the immune complexes. Therefore, the disease often relapses frequently and finally develops into End Stage Renal Failure.

Immunotherapy treats FSGS from its underlying causes. It can remove the immune complexes in kidneys, block the inflammation reaction as well as restore the impaired renal epithelial cells. It can inhibit the renal fibrosis fundamentally and stop the renal function decline from its root cause.


Immunotherapy is aims at correcting the body's own immune system and recover the abnormal protection function of the body. It does not cause side effects to patients at all.

Tips Help You Prevent Kidney Problem

Kidneys are important organs responsible for filtering the toxins from body. If they can not function normally, it will cause many health issues. This article will list some tips that can help you prevent kidney problem.

Control blood pressure:

* Blood pressure is a leading cause of Kidney Disease. Make sure your blood pressure is controlled. If you have chronic high blood pressure, it can increase your risk of developing Kidney Disease greatly. You should take proper medications to control your blood pressure at the target level 130/90 mmHg.

Drink lots of water:

* The kidneys filter the metabolic wastes from the blood and discharge them out of body in the form of urine. If the blood is not diluted well, the kidneys can not finish the function very well. If the wastes can not be filtered, it will result in various kinds of kidney problems.

Urinate frequently:

l If you have the urge to urinate, you should go to toilet at once. Holding back urine for a long time can cause bacterial growth in bladder and urinary tract resulting in infection. If the infection spreads to kidneys, it can impair the kidney function.

Avoid alcohol and smoking:

* The persons with the habits of drinking alcohol and smoking are more likely to suffer from kidney problem. Nicotine and alcohol can cause atherosclerosis resulting in high blood pressure. In turn, high blood pressure can impair kidneys. Moreover, smoking and drinking can induce a lot of toxins within the body which can easily damage the kidneys.

Regular check-ups:

* Kidney Disease usually starts silently without causing symptoms in the early stage. You should get yourself checked regularly, especially for those above 45 years old and under prolonged medications. Also the patients with Diabetes and high blood pressure also need to take regular check-ups.

Eat healthy:

* Fresh vegetables and fruits can keep you healthy and provide you with all the essential nutrients. You should include these foods in your daily diet. However, you should avoid eating junk food and reduce the drinks like coffee, carbonated drinks.


The above tips are very useful for you. If you can follow them in daily life, it can reduce the incidence of kidney damage greatly.

Tripterygium Wilfordii Slows Down the Progression of Glomerulonephritis

Glomerulonephritis refers to the inflammation of glomeruli featured with proteinuria, hematuria etc. Some researches prove that tripterygium wilfordii has some effect in slowing the progression of glomeruli.

Tripterygium wilfordii is a kind of traditional Chinese medicine and has been used for centuries as an-inflammatory agent. It contains the active constituents which are diterpenoids like triptolide and tripdiolide, alkaloids etc. The diterpene triptolide is considered the major active component in tripterygium wilfordii.

Tripterygium wilfordii has an anti-inflammation function and plays the role of immunosuppressive drugs.

In Glomerulonephritis, the immune complexes in glomeruli can cause trigger an inflammation thus damaging the epithelial cells, mesangial cells etc. Tripterygium wilfordii can inhibit the abnormal inflammation and relive the damage to renal tissues and cells. Also, tripterygium wilfordii also can block the abnormal immune response and reduce the immune complexes formation to some extent.

In addition, tripterygium wilfordii can provide some effective ingredients which can promote the self-repairing of the epithelial cells. Therefore, it can reduce the leakage of protein to some extent.

As tripterygium wilfordii is a kind of natural herb medicine, it does not cause any adverse side effects to the patients with Glomerulonephritis.

Although tripterygium wilfordii has so many effects in the treatment of Glomerulonephritis, the patients can not get a good recovery just relying on this single herb medicine. In fact, in traditional Chinese medicine, every prescription is composed of four to sixty types of herb medicines. Those herb medicines are interacted and influenced to act and treat the disease from many aspects.


If you want to learn more about traditional Chinese medicine like, you can leave a message below.

How to Treat Immune Mediated Kidney Disease

Immune mediated kidney disease is caused by immune dysfunction or abnormality. Therefore, the key for treating this kind of kidney disease is to correct the immune system and suppress the abnormal immune response.

In healthy condition, immune system plays an important role in protecting our body from the foreign pathological substances. When opathogenic microorganisms invade into body, the immune system can activate the relative antibodies to kill them. Therefore, the human body can keep in a healthy state.

However, in some cases, the immune system performs abnormally and loses the protection function. The antibodies can not tell the foreign pathological substances and that of the body's own. As a result, the antibodies complexes or antigens and antibodies complexes may enter into glomeruli and deposit different parts of the glomeruli. Afterwards, the body tries to remove the immune complexes from body by mounting an inflammation. The immune complexes can impair the glomeruli and renal function thus leading to immune mediated kidney diseases. For different locations of the immune complexes, it presents different types of kidney diseases like IgA Nephropathy, Lupus Nephropathy etc.

To correct the immune dysfunction and suppress the abnormal immune complexes, immunotherapy is recommended to the patients with immune mediated kidney disease.
Immunotherapy is not a single treatment method, but a complete treatment system and process.

In immunotherapy, blood purification can clear up the immune complexes associating in blood. In this way, it can prevent the further immune complexes in kidneys. However, blood purification can not remove the deposited immune complexes deposited in kidneys at all.

In immune regulation, Micro-Chinese Medicine Osmotherapy plays the main role in removing the deposited immune complexes. On one hand, it can degrade the immune complexes and improve blood circulation. Therefore, the degraded immune complexes will be excreted out of body finally through systemic circulatory system.

However, as the kidneys have been impaired by the deposited immune complexes, the patients should take relative treatments to restore those damaged renal functional cells. Immunotherapy refers to infusion the healthy Immunotherapy into the patients'body. Also, they can supply some nutrients to the self-repairing of the damaged cells.


Immunotherapy treats immune mediated kidney disease from its root causes. Therefore, it can bring a favorable therapeutic effect for the patients.