How does Polycystic Kidney Disease Develop into Renal Fibrosis

Any kind of kidney disease will follow the process of renal fibrosis, which is very difficult to treat once they progress into Urmeia( End-Stage Renal Failure). During this period, the kidney functions have been greatly damaged. However, if patients with Polycystic Kidney Disease do not receive positive measures to control it, it can also develop into Uremia without exception. How does Polycystic Kidney Disease develop into renal fibrosis and when is the best time to prevent the occurrence to renal fibrosis.

Before half of the nephrons are damaged, people do not present abnormal symptoms, while, renal fibrosis has already developed into the middle stage. If 80% of the kidneys are damaged, patients then enter into the Renal Failure stage and a lot of symptoms like acidosis will appear. The kidneys will be in a state of ischemia and anemia, which triggers the onset of renal fibrosis. A series of renal toxicity factors and growth factors( PDGF,TGF-β) will be produced at this period, which will stimulate the epithelial cells phenotype’s transformation, producing mybrofibroblasts and secrecting extracellular matrix (ECM).

Therefore, it is important to prevent the process of renal fibrosis, which means to reverse the damaged kidney intrinsic cells and recover the kidney functions. As for the prevention of renal fibrosis caused by Polycystic Kidney Disease, it has the following aspects.

1. Shrink the cysts to reduce the pressure on the kidneys.

2. Repair the damaged kidney tissues.

It is better to treat Polycystic Kidney Disease as early as possible especially when the kidney function has not been damaged yet. The life expectancy can prolong even with cysts in their kidneys.


Here we recommend Micro-Chinese Medicine Osmotherapy and Immunotherapyation in Shijiazhuang Kidney Disease Hospital. Many patients have got a satisfactory result through the two therapies. The kidney cysts can shrink effectively and decrease the damage of kidney functions to the largest extent. If you have other questions of your illness condition or our therapies, please send email to kidney-treatment@hotmail.com.

Polycystic Kidney Disease Patients: Stay Away from Alcohol

Numerous studies show that drinking alcohol can irritate our kidneys greatly especially wine and liquor. So patients with Polycystic Kidney Disease should quit it.

Experts say that the alcohol can directly stimulate the activity of polycystin and accelerate the secretion of cyst fluid. Therefore, the cyst will grow more vigorously.

Nowadays, we take part in more and more parties and nearly at every party, alcohol is necessary. Therefore, experts from Shijiazhuang Kidney Disease Hospital warn the patients with Polycystic Kidney Disease: stay away from alcohol.

1. Drinking frequently can elevate the blood pressure.

2. Drinking too much will make our body cells lose too much bond water.

3. The dysfunction of creatinine metabolism in the muscles will occur, leading to the elevation of serum creatinine in the blood.

4. Acidic materials will be produced at the process of decomposing alcohol, leading to metabolic acidosis. Thus, a lot of symptoms like vomiting, poor appetite, deprementia, and headache will present.

5. Long time drinking will lead to the dysfunction of platelets, anemia and bleeding.

6. Disorder of gastrointestinal absorption will present; long time nutritional deficiency will lead to the lack of Vitamin B1, B2 and folic acid in our body, while the discharge of Vitamin B6 will increase.

7. Hyperlipidaemia and atherosclerosis can also present.

What is more, drinking too much can also influence the nitrogen balance of our body and increase the urea nitrogen in the blood, which will give too much burden to the kidneys. It is no big thing for a normal person. However, it can claim the life of patients with Polycystic Kidney Disease. So, stay away from alcohol.


However, just stay away from alcohol is far from treating Polycystic Kidney Disease. Patients should receive proper treatment as early as possible if they are identified with Polycystic Kidney Disease if they want to prolong their life expectancy. Here we recommend Micro-Chinese Medicine Osmotherapy and Immunotherapy in Shijiazhuang Kidney Disease Hospital. Please send email to kidney-treatment@hotmail.com.

Several Symptoms will Present When One Gets Polycystic Kidney Disease

There are no obvious manifestations at the early stage of Polycystic Kidney Disease, which does not mean the illness condition is not progressing. Once obvious manifestations present, the enlarging cysts have caused great damage to the kidneys. From the above, we can see how important it is to have a clear knowledge of the symptoms of Polycystic Kidney Disease. Experts from Shijiazhuang Kidney Disease Hospital will give you the description of the symptoms in detail.

Abnormality in urine

It is mainly showing up as hematuria (blood in urine) or proteinuria( protein in urine), which is one of the early symptoms. The proteinuria(protein in urine) is very common for patients of Polycystic Kidney Disease and it is caused by the damage of the filtration function of glomeruli. While, the reason why hematuria presents is the increasing cysts press each other and finally rupture, leading to bleeding of kidneys. Generally, patients will present gross hematuria without pain and it is intermittent and light. What is more, frequent urination, excessive urination at night will present, which might be closely related with the kidneys’ concentration function.

Abdominal mass

When the kidneys are large to a certain extent, patients can feel numerous mass of different sizes on one side or both sides of abdomen. They will move when patients are breathing and pressing pain may occur when the masses are accompanied with infection.

Anemia

Most patients with Polycystic Kidney Disease will suffer from anemia from light to severe, which is often accompanied with excessive urination at night. This is related with the reduction of erythrogenins(EPO) in the kidneys.

High blood pressure

High blood pressure is one of the most frequent symptoms, and 50%-60% patients with Polycystic Kidney Disease will present it. High blood pressure usually occurs when the kidneys function normally, which is often accompanied with headache, dizziness. It is closely related with the resistance of renin-angiotensin system (RAS).

Discomfort in back or sides

This symptom usually occurs at the early stage of Polycystic Kidney Disease, which shows up as pressing pain in the back or abdomen. This is caused by the enlargement of the kidneys pulling the renal capsule.

Symptoms of Urinary Tract System

This symptoms can be shown up as anuria, frequent urine, urgent urine, pain when urination, hematuria, excessive urine at night and less urine.

Those above are the main symptoms of Polycystic Kidney Disease. Experts from Shijiazhuang Kidney Disease Hospital suggest patients with Polycystic Kidney Disease receive treatment as early as possible.


The earlier the treatment, the better the result.

Polycystic Kidney Disease: Causes and Formation

As a hereditary disease, the main cause of Polycystic Kidney Disease is the abnormality of the 16th chromosome. This faulty condition exists from the fetal stage and it will last for the rest of their lives. Most patients begin to present symptoms when they are about 40 years old.

The cysts originate from the tubules which include the distal tubules and proximal tubules. The properties of the cyst fluid can be different if they originate from different positions. The cyst fluid may include Na+, K+, CI-, H+, serum creatinine, urea, etc， which is similar to serum plasma if the cysts originate from proximal tubules. While, the Na+、K+ concentration is low and the CI-, H+, serum creatinine, urea concentration is high if the cysts are on the proximal tubules.

What is more, a lot of external factors can also trigger the occurrence of Polycystic Kidney Disease such as infection, taking drugs of renal toxicity, overtired, emotional recurrence and unreasonable diet etc. When the following condition occurs, a series of changes will happen in the kidneys.

1. The metabolism of tubules epithelial cells will be changed and growth factors will be produced, leading to the proliferation of cells.

2. The obstruction of renal tubules, retention of fluids and swelling can work together to form cysts.

3. More and more fluids will accumulate in the tubules.

4. The fluids are easy to go in but difficult to go out.

The inner environment will not change without the external factors’ trigger. That is why many people do not present cysts until they are 30 or more years old.

If Polycystic Kidney Disease is not controlled well, a lot of complications can be induced. To prolong the life expectancy, patients should receive treatment as early as possible. The earlier, the better. Micro-Chinese Medicine Osmotherapy and Immunotherapy can treat Polycystic Kidney Disease and shrink cysts to a large extent. Compared with western methods, these therapies do not cause any side effects. You can directly send email to kidney-treatment@hotmail.com if you have other questions.

Patients with Polycystic Kidney Disease(PKD) Should Pay More Attention to Its Complications

Polycystic Kidney Disease (PKD) is a common genetic disease. In most cases, the patients do not have symptoms in the early time so they often just pay no attention to the disease. However, as the disease develops, a series of horrible complications are approaching them silently.

1. Back pain

As the cysts enlarge, they will oppress the kidney tissues and neighboring organs thus causing pain. What’s worse, some big cysts will rupture thus causing bleed in cysts, which can cause the patients feel violent pain suddenly. In the traditional medicines, the doctors just suggest pain killer to remit the pain or surgery to shrink the cysts. However, those methods only provide the temporary relief and can not solve the problem from its root.

2. Headache

Some patients with PKD have severe headache that might be caused by cerebral aneurysm- balloon of blood vessels in brain. These aneurysms could rupture thus causing severe headache and even death. Hypertension is an important factor in causing aneurysm. Therefore, the patients with PKD must control their blood pressure within the normal range.

3. Urinary tract infection

Patients with PKD often have urinary tract infection, which is also a cause of pain. Once patients have urinary tract infection, they should seek treatment at once because infection can spread to cysts. It will be more difficult to treat the infection in cysts for much antibiotics can not penetrate the cysts.

4. Hypertension

As the cysts enlarge, they will oppress the kidney tissues and affect the normal secretion of renin thus causing Hypertension. High blood pressure is an important factor in aggravating the disease. If the patients can keep a healthy lifestyle and take medicines rationally to make their blood pressure in control, it will slow down PKD progression.

5. Hematuria

With the cysts enlargement, they will oppress kidney and neighboring tissues thus causing the small blood vessels to rupture. As kidney intrinsic cells are damaged and lose their barrier function, the red blood cells will leak into urine. In addition, some patients with PKD may have urinary tract infection and kidney stone, which also can cause blood in urine.


However, many patients with PKD just treat these symptoms, but do not treat the disease from its root. As a result, their renal function will decline gradually thus developing into Renal Failure at last.

How to Deal With Complications of Polycystic Kidney Disease

Patients with Polycystic Kidney Disease tend to present a lot of complications like: proteinuria (blood in urine), hematuria(blood in the urine), high blood pressure, which can greatly harm our body. Then, how to deal with these complications caused by Polycystic Kidney Disease? We will have a comparison of the present therapies for you.

1. The general therapy

There is no need for most patients to change their life style or limit their activities. If the kidneys have an obvious enlargement, they should avoid injuries of abdominal sides for fear of the rupture of kidney cysts.

2. The treatment of Hematuria( Blood in Urine)

When Polycystic Kidney Disease patients present hematuria, they should take further examinations to confirm and reduce their outdoor activities and have good rest. If it can not be controlled and relapses a lot, they can consider having embolization of renal artery.

3. Treatment of Infections

The infections of renal parenchyma and infections of the cysts are the main complications of Polycystic Kidney Disease, which should be dealt with antibiotics.

4. High blood pressure treatment

The main reason why high blood pressure occurs is the disorder of angiotensin system (RAS). The patients should take some anti-hypertension medicines.

5. Top Decompression

This surgery can reduce the pressure caused by the cysts on the kidneys so that most left nephrons can avoid being pressed and damaged. It can improve the state of ischemia and anemia to some extent. However, this surgery can not clear the small cysts, which will grow more quickly when the big cysts are cleared. If patients have presented azotemia or the illness condition has progressed into late stage-Uremia, it is meaningless to have this surgery. The already damaged kidneys can not bear the attack of the surgery, which will make things worse.

6. Dialysis and Kidney Transplantation

When Polycystic Kidney Disease progresses into End-Stage Renal Failure, patients should receive maintenance dialysis to discharge the wastes in their body.
Because the various complications of Polycystic Kidney Disease patients, they will have a high risk if they receive kidney transplantation.

However, the above methods all have disadvantages and can not completely treat Polycystic Kidney Disease.

7. Unique treatment in Shijiazhuang kidney disease hospital


Micro-Chinese Medicine Osmotherapy and Immunotherapyation can shrink the cysts from its root and effectively alleviate its complications. The Micro-Chinese Medicine Osmotherapy can provide an environment for the function of Immunotherapy. It is a perfect combination if they are combined to treat Polycystic Kidney Disease. The cysts can shrink from root and do not relapse.We are confident to say it is the best choice to treat Polycystic Kidney Disease up to now.

Micro-Chinese Medicine Osmotherapy Brings Me New Hope for Life

Polycystic Kidney Disease (PKD) is a genetic disease. Nearly all patients with the disease think that there is no treatment for the disease. Therefore, they just give up treatment when they are diagnosed with the disease and let their disease develop into Renal Failure gradually. However, if you open your mind and seek a new therapy for your treatment, you will be able to find hope for life. In the following article, a patient with PKD will tell his own recovery experience.
I am Zhoubin from Hebei Province. One day, I touched a mass on my abdomen when showering. I was frightened and worried whether I had tumor. But I did not have any abnormal symptom so did not pay any attention to the mass at all. However, the mass became bigger after a period of time.

So I went to my local hospitals to do check. The check result shocked me so much. I was diagnosed with PKD. By ultrasound, my left kidney is 16 centimeters and the right is 15 centimeter. The doctor told me that PKD was genetic disease and there was no effective treatment for the disease. He suggested me to shrink the cysts with puncture, but this therapy could not treat my disease from its root and the cysts would grow up very soon. What’s worse, the doctor analyzed the risk of puncture. I felt so despaired and just want give up the disease. I thought that PKD was genetic disease and I had no possibility of recovery at all.

In the later days, I searched much information on PKD on internet. The serious effect bringing to patients made was unimaginable. I could not sleep or eat well at all in those days. I was afraid that my disease developed into Renal Failure. Therefore, I made a decision to the disease immediately.

I looked up lots of materials and consulted so many doctors. However, they just suggested puncture or cyst decortication. I nearly lost my confidence in treating the disease in those days. One day, I found Micro-Chinese Medicine Osmotherapy on net suddenly. I was so interested in this therapy because the patients did not need operation at all, but I had more doubt than happiness about the therapy at that moment. I thought that so many famous hospitals could not tackle this disease problem. Did a private hospital can treat the disease? After several days’ mental struggle, I decided to have a try no matter what the result was.
On June 23rd, I came to Shijiazhuang Kidney Disease Hospital to receive treatment. The doctor told me that my blood pressure (150/90 mmHg) had increased slightly caused by the enlarged cysts. If I was sensitive to Chinese medicines, my cysts would shrink gradually and blood pressure would declined to the normal range.

After about 20 days’ hospitalization, my disease improved so much. When doing B-ultrasound, my left kidney was 12 centimeters and the right was 13 centimeters. And my biggest cyst shrank to 3CM. Moreover, I discharged so much floc in the urine. The doctor told me that it was the toxins and wastes that accumulated in my body. As my renal function improved so they could be discharged by kidney. What made me happy was that my blood pressure also declined to 120/80mmHg.


Now I want to share my recovery experience to all patients with PKD and hope all patients can get a good treatment. If you do not give up, you will be able to find more hope for life.