Hypertension of Polycystic Kidney Disease (PKD)

Polycystic Kidney Disease (PKD) belongs to hereditary Kidney Disease, kind of congenital abnormality. Cysts of Polycystic Kidney Disease (PKD) are mainly caused by eccyliosis of renal parenchyma and renal structure, with different involvement of each kidney. These cysts compress surrounding healthy renal tissue, which can cause renal ischemia and anoxia as well as low renal perfusion. Then Hypertension of Polycystic Kidney Disease (PKD) happens, which means that Polycystic Kidney Disease (PKD) patients begin to suffer from Hypertension.

Through observation, many grapelike cysts with different sizes spread over the whole renal tissue, and the volume of cysts is much larger than the volume of renal parenchyma. Kidney enlarges obviously and light yellow liquid can be found in cyst at kidney section. Due to internal bleeding, liquid color may be red or brown, contenting tiny protein, chloride, cholesterin and light urea. Cysts may be open to each other, but isolated with renal pelvis. Cystic pressure on renal tissue can cause renal tubule atrophy and sclerosis, damage glomerulus and renal function. Besides, these cysts also compress kidney blood vessels, reducing local blood flow. Therefore, there will be a high concentration of angiotensin with shrunk blood vessel, leading to Hypertension. In some degree, it is a vicious circle between Hypertension and renal function injury.


Based on the above, generally, once Polycystic Kidney Disease (PKD) patients get Hypertension, it means that renal function is about to decline or has already been damaged. For this reason, patients should pay more attention on controlling Hypertension.