FSGS: Is It an Immunological Disease

More than 95% of kidney diseases are immunological disease and FSGS is not an exception. In order to give suitable treatment, the diagnosis like this judgment is very important. So for patients with FSGS, treatment should focus on immune regulation in order to achieve a good effect.

Overview of FSGS

It is short for focal segmental glomerulosclerosis that means some sections of kidney filters are scarred. After reading this explanation, you can know the general situation about this disease. How does FSGS associate with immunological disease?

Due to unhealthy diet or life style, their immune system is out of order and patients’ immunity is lower than before. In this physical condition, people are very easy to suffer diseases, such as infections or a cold. If their innate immune system is good, immune complexes formed during infections will be removed by immune cells. However, in patients with FSGS, the immune complexes have to stay in body and would arouse renal failure once they deposit in kidney tissues.

Inflammatory mediators will accumulate around immune complexes in kidney tissues in order to remove them. However, this inflammation will hurt kidney tissues meanwhile. When kidney cells are damaged, the filtering ability cannot be done normally. Many valuable substances in the blood will be leaked from the blood. Furthermore, over time the kidney filters would be scarring and cause loss of kidney function. Once they lose about 50%, FSGS is coming.

Immunotherapy is the correct treatment for immunological disease—FSGS. It mainly contains Immunodepression, immune regulation and immune protection.


Immunodepression will give patients some immunosuppressive agents to restrain renal inflammation in order to protect kidney cells. Furthermore, these agents are regularly needed to keep a good situation in kidneys. However, kidney cannot tolerate immune complexes for a long time. Immune regulation is essential to turn immune system to normal so as to block renal inflammation from the root. If the kidney has a serious hurt, immune protection is provided. It adopts Immunotherapy which does not only provide new kidney cells but also rebuild a new immune system to keep healthy for a long time.