What immunosuppressants do with lupus nephritis

What immunosuppressants do with lupus nephritis

Lupus nephritis is a renal damage caused by systemic lupus erythematosus (SLE), and this is the main complication and cause of SLE death. This is a kind of nephritis due to disorders of the immune system and the deposition of immune complexes in the kidneys.

In the body of patients with SLE, lymphocyte B is highly active and has a rapid proliferation rate. They will produce many antibodies, such as antinuclear antibodies. These antibodies will attack the autoantigens and form immune complexes that can precipitate in all organs and tissues, induce immune responses and damage these tissues and organs.

Immune complexes that precipitate in the renal glomeruli activate the supplements through the classical pathway. In addition, leukocytes, platelets and cytokines will further aggravate inflammation in the kidneys and worsen kidney damage.

Since we know the main cause of kidney damage in lupus nephritis, we should understand why immunosuppressants are used. As the name suggests, immunosuppressants generally have functions for inhibiting immune responses, controlling the proliferation and function of immune cells (T cells, B cells, macrophages, etc.). Immunosuppressants are mainly used to treat rejection after organ transplantation and autoimmune diseases such as rheumatoid arthritis and SLE, etc.

In the clinic, treatment of lupus nephritis is mainly taken by immunosuppressants and medications that can control and treat inflammation. The following are the main immunosuppressants.

- Cyclosporin

- Rapamycin

- Mycophenolate Mofetil

- Mizoribine

- Cyclophosphamide

However, simultaneously with the inhibition of abnormal immune responses, immunosuppressants can also suppress normal immune responses and reduce the immunity of patients and make patients more susceptible to attacks by various bacteria and viruses. Moreover, the symptoms often return easily if these immunosuppressants stop. One solution is to add some Chinese medicinal herbs that can not only alleviate the side effects of long-term use of these immunosuppressants, but can also regulate immune system disorders and improve the immunity of patients. Because of this, you should carefully consult with your doctor before taking any additional medications to avoid unwanted and adverse chemical reactions of these medicinal herbs with these patients. Various medicines will be prescribed by advanced Chinese herbalists depending on the particular condition of the patient's illness, physical condition and what immunosuppressants the patients have, etc. Our mail is Asya.yue@mail.ru, Whatsapp / viber +8613292893707.