Causes of Bilateral Polycystic Kidney Disease

Polycystic Kidney Disease is a kind of hereditary Kidney Disease with great damage, and frequently related to bilateral kidneys. Besides hereditary factors, there are still some other factors that can cause Polycystic Kidney Disease.
Epithelial cells of renal tubule and cells on cyst wall can be changed by cyst gene, which can cause the following results:

Ⅰ. Cyst gene can affect Na-K-ATPase of tubule epithelial cells, which can increase inner fluid of renal tubule and make cells on cyst wall secrete fluid.
Ⅱ. Epithelial cells of renal tubule proliferate continuously, forming polypoid lesion which can cause renal tubule obstruction, and the obstruction can lead to fluid retention which can bulge tubule, and then cysts form.

Ⅲ. Infections and toxin can act on renal tubule, which can activate cyst gene and change tubule cells metabolism, or even cause epithelial cells apoptosis. Apoptosis cells can also lead to obstruction after they slough off.

Ⅳ.Epithelial cells can secrete series of bioactive substances which can increase cyst fluid secretion.

Ⅴ. Cyst gene can lead to abnormal Extracellular Matrix and change the condition of basement membrane and tubule wall, which can provide a favorable environment for cyst growth.

Micro-Chinese Medicine is a distinctive Chinese Medicine Treatment, which can treat the disease from its primary cause, namely Renal Fibrosis. It mainly treats this disease by the following methods.

Firstly, Micro-Chinese Medicine takes the medication way of micronized Chinese Medicine combined with external osmosis on renal area. Smashing and decoction are adopted in the process of Traditional Chinese Medicine Treatment. While our hospital takes high-technology to micronize medicine into more refined powder.
Through this method, medicine can be absorbed easily. Besides, active substances of Chinese Medicine can be sent into renal lesion directly by the method of external osmosis on renal area, which can get a higher medicine utilization rate.


Secondly, mainly depending on Micro-Chinese Medicine and puting Western Medicine in a supportive role is the treatment principle that our hospital insists. As for PKD patients who suffer from Hypertension and Anemia, they need take Western Medicine to control their symptoms in order to make Micro-Chinese Medicine play a more effective role in recovering renal inherent cells and inhibiting secretion of cyst fluid.